4YJ3

Crystal structure of tubulin bound to compound 2

Summary for 4YJ3

Related4YJ2
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (12 entities in total)
Functional Keywordsalpha-tubulin, beta-tubulin, stathmin, mi-181, cell cycle inhibitor complex, microtubule, cytoskeleton, cell cycle
Biological sourceRattus norvegicus (Rat)
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Cellular locationCytoplasm, cytoskeleton P81947 Q6B856
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight264817.77
Authors
McNamara, D.E.,Torres, J.Z.,Yeates, T.O. (deposition date: 2015-03-03, release date: 2015-05-27, Last modification date: 2017-09-20)
Primary citation
McNamara, D.E.,Senese, S.,Yeates, T.O.,Torres, J.Z.
Structures of potent anticancer compounds bound to tubulin.
Protein Sci., 24:1164-1172, 2015
PubMed: 25970265 (PDB entries with the same primary citation)
DOI: 10.1002/pro.2704
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28040.0%0.2%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution