4YHQ

Crystal structure of multidrug resistant clinical isolate PR20 with GRL-5010A

Summary for 4YHQ

Entry DOI	10.2210/pdb4yhq/pdb
Descriptor	Protease, (3R,3aS,6aS)-4,4-difluorohexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, YTTRIUM ION, ... (7 entities in total)
Functional Keywords	hiv protease, mutant, drug resistant, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 group M subtype (HIV-1)
Total number of polymer chains	2
Total formula weight	22856.80
Authors	Agniswamy, J.,Weber, I.T. (deposition date: 2015-02-27, release date: 2015-06-10, Last modification date: 2023-09-27)
Primary citation	Agniswamy, J.,Louis, J.M.,Shen, C.H.,Yashchuk, S.,Ghosh, A.K.,Weber, I.T. Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. J.Med.Chem., 58:5088-5095, 2015 Cited by PubMed: 26010498 DOI: 10.1021/acs.jmedchem.5b00474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation