Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue G10 A 201 |
| Chain | Residue |
| A | LEU23 |
| A | ILE50 |
| A | VAL82 |
| A | HOH302 |
| A | HOH303 |
| A | HOH304 |
| A | HOH305 |
| A | HOH341 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| A | ASP25 |
| B | ASP29 |
| B | ASN30 |
| B | ILE32 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | VAL82 |
| B | HOH202 |
| B | HOH212 |
| B | HOH238 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASN30 |
| A | ILE32 |
| A | GLY48 |
| A | GLY49 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue Y1 A 202 |
| Chain | Residue |
| A | GLU34 |
| A | ASP35 |
| A | GLU58 |
| A | ASP60 |
| A | Y1203 |
| A | CL204 |
| A | CL205 |
| A | HOH357 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue Y1 A 203 |
| Chain | Residue |
| A | ASP35 |
| A | GLU58 |
| A | ASP60 |
| A | Y1202 |
| A | CL204 |
| A | CL205 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | GLU34 |
| A | ASP35 |
| A | LYS45 |
| A | GLU58 |
| A | Y1202 |
| A | Y1203 |
| A | HOH308 |
| A | HOH357 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 205 |
| Chain | Residue |
| A | ASP35 |
| A | GLU58 |
| A | ASP60 |
| A | Y1202 |
| A | Y1203 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 206 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH330 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 207 |
| Chain | Residue |
| A | GLY73 |
| A | THR74 |
| A | THR89 |
| A | GLN92 |
| A | HOH312 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 208 |
| Chain | Residue |
| A | PRO1 |
| A | GLN2 |
| A | GLY40 |
| A | GLN61 |
| A | HOH362 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue Y1 B 101 |
| Chain | Residue |
| B | GLU34 |
| B | ASP35 |
| B | LYS43 |
| B | GLU58 |
| B | ASP60 |
| B | Y1102 |
| B | HOH210 |
| B | HOH234 |
| B | HOH272 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue Y1 B 102 |
| Chain | Residue |
| B | ASP35 |
| B | LYS43 |
| B | GLU58 |
| B | ASP60 |
| B | Y1101 |
| B | HOH210 |
| B | HOH272 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 103 |
| Chain | Residue |
| B | GLY16 |
| B | GLY17 |
| B | HOH245 |
| B | HOH284 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 104 |
| Chain | Residue |
| B | LYS7 |
| B | ARG8 |
| B | HOH247 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 105 |
| Chain | Residue |
| A | TRP6 |
| B | ARG87 |
| B | ASP88 |
| B | HOH208 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADNTIF |
| Chain | Residue | Details |
| A | ALA22-PHE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12924029","evidenceCode":"ECO:0000269"}]} |
