4YHH

Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with tigecycline

Summary for 4YHH

• Entry DOI: 10.2210/pdb4yhh/pdb
• Related: 2ZM6
• Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (24 entities in total)
• Functional Keywords: protein synthesis, ribosome, antibiotic
• Biological source: Thermus thermophilus HB8; More
• Total number of polymer chains: 21
• Total formula weight: 765474.86

Authors

Schedlbauer, A.,Kaminishi, T.,Ochoa-Lizarralde, B.,Dhimole, N.,Zhou, S.,Lopez-Alonso, J.P.,Connell, S.R.,Fucini, P. (deposition date: 2015-02-27, release date: 2015-04-08, Last modification date: 2024-01-10)

• Primary citation: Schedlbauer, A.,Kaminishi, T.,Ochoa-Lizarralde, B.,Dhimole, N.,Zhou, S.,Lopez-Alonso, J.P.,Connell, S.R.,Fucini, P.; Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.; Antimicrob.Agents Chemother., 59:2849-2854, 2015; PubMed: 25753625; DOI: 10.1128/AAC.04895-14

Experimental method

X-RAY DIFFRACTION (3.417 Å)