4YC4

Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with nucleotide analog

4YC4 の概要

• エントリーDOI: 10.2210/pdb4yc4/pdb
• 関連するPDBエントリー: 4PLA
• 分子名称: Phosphatidylinositol 4-kinase type 2-alpha,Lysozyme,Phosphatidylinositol 4-kinase type 2-alpha, [(1S,3S,4S)-3-(6-amino-9H-purin-9-yl)bicyclo[2.2.1]hept-1-yl]methanol, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: kinase, complex, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor : Q9BTU6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63927.42

構造登録者

Klima, M.,Boura, E. (登録日: 2015-02-19, 公開日: 2015-07-15, 最終更新日: 2024-05-08)

• 主引用文献: Klima, M.,Baumlova, A.,Chalupska, D.,Hrebabecky, H.,Dejmek, M.,Nencka, R.,Boura, E.; The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.; Acta Crystallogr.,Sect.D, 71:1555-1563, 2015; PubMed: 26143926; DOI: 10.1107/S1399004715009505

実験手法

X-RAY DIFFRACTION (2.58 Å)