4YBH

Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6

4YBH の概要

• エントリーDOI: 10.2210/pdb4ybh/pdb
• 関連するPDBエントリー: 4P2Y
• 分子名称: Advanced glycosylation end product-specific receptor, Protein S100-A6, ZINC ION, ... (7 entities in total)
• 機能のキーワード: signaling complex, pattern recognition receptor, dimerization, ef-hand calcium binding protein, immunoglobulin domain, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 10: Cell membrane ; Single-pass type I membrane protein : Q15109; Nucleus envelope: P06703
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43894.57

構造登録者

Yatime, L.,Andersen, G.R. (登録日: 2015-02-18, 公開日: 2016-03-02, 最終更新日: 2024-01-10)

• 主引用文献: Yatime, L.,Betzer, C.,Jensen, R.K.,Mortensen, S.,Jensen, P.H.,Andersen, G.R.; The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.; Structure, 24:2043-2052, 2016; PubMed: 27818100; DOI: 10.1016/j.str.2016.09.011

実験手法

X-RAY DIFFRACTION (2.4 Å)