4Y94
Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate
Summary for 4Y94
| Entry DOI | 10.2210/pdb4y94/pdb |
| Related | 4Y93 4Y95 |
| Descriptor | Non-specific protein-tyrosine kinase, INOSITOL HEXAKISPHOSPHATE, ZINC ION, ... (4 entities in total) |
| Functional Keywords | btk, ph domain, tyrosine kinase, inositol hexakisphosphate, transferase |
| Biological source | Bos taurus (Bovine) |
| Total number of polymer chains | 4 |
| Total formula weight | 84866.56 |
| Authors | Wang, Q.,Kuriyan, J. (deposition date: 2015-02-16, release date: 2015-03-18, Last modification date: 2024-02-28) |
| Primary citation | Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4:-, 2015 Cited by PubMed: 25699547DOI: 10.7554/eLife.06074 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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