4Y94

Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035556	biological_process	intracellular signal transduction
B	0035556	biological_process	intracellular signal transduction
C	0035556	biological_process	intracellular signal transduction
D	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue IHP B 201

Chain	Residue
A	LYS71
B	LYS12
B	ASN24
B	LYS26
B	ARG28
B	TYR39
B	LYS53

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 202

Chain	Residue
B	CYS155
B	CYS165
B	HIS143
B	CYS154

---

site_id	AC3
Number of Residues	12
Details	binding site for residue IHP C 201

Chain	Residue
C	LYS12
C	SER14
C	GLN15
C	ARG28
C	TYR39
C	LYS53
C	HIS126
C	ASN130
C	HOH301
C	HOH302
C	HOH313
D	MET1

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 202

Chain	Residue
C	HIS143
C	CYS154
C	CYS155
C	CYS165

---

site_id	AC5
Number of Residues	8
Details	binding site for residue IHP A 501

Chain	Residue
A	LYS36
A	LYS52
A	SER55
B	LYS36
B	TYR40
B	ARG49
B	LYS52
B	GLU119

---

site_id	AC6
Number of Residues	12
Details	binding site for residue IHP A 502

Chain	Residue
A	LYS12
A	SER14
A	ASN24
A	LYS26
A	ARG28
A	TYR39
A	LYS53
A	HIS126
A	ASN130
A	HOH601
A	HOH605
B	GLY0

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	HIS143
A	CYS154
A	CYS155
A	CYS165

---

site_id	AC8
Number of Residues	7
Details	binding site for residue IHP D 201

Chain	Residue
D	LYS12
D	SER14
D	GLN15
D	ASN24
D	ARG28
D	TYR39
D	LYS53

---

site_id	AC9
Number of Residues	8
Details	binding site for residue IHP D 202

Chain	Residue
C	ALA2
C	LYS36
C	LYS52
C	SER55
D	LYS36
D	TYR40
D	ARG49
D	LYS52

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN D 203

Chain	Residue
D	HIS143
D	CYS154
D	CYS155
D	CYS165

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