4Y85

Crystal structure of COT kinase domain in complex with 5-(5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine

Summary for 4Y85

Entry DOI	10.2210/pdb4y85/pdb
Related	4Y83
Descriptor	Mitogen-activated protein kinase kinase kinase 8, 5-[5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1,3,4-oxadiazol-2-amine (3 entities in total)
Functional Keywords	cot, tpl-2, map3k8, kinase, inhibitor, complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	113854.55
Authors	Gutmann, S.,Hinniger, A. (deposition date: 2015-02-16, release date: 2015-05-06, Last modification date: 2019-05-29)
Primary citation	Gutmann, S.,Hinniger, A.,Fendrich, G.,Druckes, P.,Antz, S.,Mattes, H.,Mobitz, H.,Ofner, S.,Schmiedeberg, N.,Stojanovic, A.,Rieffel, S.,Strauss, A.,Troxler, T.,Glatthar, R.,Sparrer, H. The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold. J.Biol.Chem., 290:15210-15218, 2015 Cited by PubMed: 25918157 DOI: 10.1074/jbc.M115.648097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation