4Y85
Crystal structure of COT kinase domain in complex with 5-(5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Mitogen-activated protein kinase kinase kinase 8 | polymer | 332 | 37635.2 | 3 | UniProt (P41279) Pfam (PF00069) | Homo sapiens (Human) | Cancer Osaka thyroid oncogene,Proto-oncogene c-Cot,Serine/threonine-protein kinase cot,Tumor progression locus 2,TPL-2 |
| 2 | D, E, F (A, B, C) | 5-[5-(1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1,3,4-oxadiazol-2-amine | non-polymer | 316.3 | 3 | Chemie (499) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
A, B, C: 66 - 395 (UniProt: P41279)
| PDB | External Database | Details |
|---|---|---|
| Gly 64 | - | expression tag |
| Pro 65 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112905.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 949.0 | |
| All* | Total formula weight | 113854.5 |
