4Y7R
Crystal structure of WDR5 in complex with MYC MbIIIb peptide
Summary for 4Y7R
Entry DOI | 10.2210/pdb4y7r/pdb |
Descriptor | WD repeat-containing protein 5, MYC MbIIIb peptide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | myc wdr5 cancer, dna binding protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P61964 |
Total number of polymer chains | 2 |
Total formula weight | 35464.16 |
Authors | Sun, Q.,Phan, J.,Olejniczak, E.T.,Thomas, L.R.,Fesik, S.W.,Tansey, W.P. (deposition date: 2015-02-16, release date: 2015-04-15, Last modification date: 2023-09-27) |
Primary citation | Thomas, L.R.,Wang, Q.,Grieb, B.C.,Phan, J.,Foshage, A.M.,Sun, Q.,Olejniczak, E.T.,Clark, T.,Dey, S.,Lorey, S.,Alicie, B.,Howard, G.C.,Cawthon, B.,Ess, K.C.,Eischen, C.M.,Zhao, Z.,Fesik, S.W.,Tansey, W.P. Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. Mol.Cell, 58:440-452, 2015 Cited by PubMed: 25818646DOI: 10.1016/j.molcel.2015.02.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.898 Å) |
Structure validation
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