4Y6Q

Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose

Summary for 4Y6Q

• Entry DOI: 10.2210/pdb4y6q/pdb
• Related: 4Y6L 4Y6O
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate, ... (4 entities in total)
• Functional Keywords: sirtuin, sirt, nad-dependent deacetylase, 2-o-myristoyl-adp-ribose, acyl-adp-ribose, complex, deacylase, intermediate, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 136145.21

Authors

Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2015-02-13, release date: 2016-01-06, Last modification date: 2023-11-08)

• Primary citation: Feldman, J.L.,Dittenhafer-Reed, K.E.,Kudo, N.,Thelen, J.N.,Ito, A.,Yoshida, M.,Denu, J.M.; Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.; Biochemistry, 54:3037-3050, 2015; PubMed: 25897714; DOI: 10.1021/acs.biochem.5b00150

Experimental method

X-RAY DIFFRACTION (1.9 Å)