4Y6M
Structure of plasmepsin II from Plasmodium falciparum complexed with inhibitor PG418
Summary for 4Y6M
Entry DOI | 10.2210/pdb4y6m/pdb |
Related | 4CKU |
Descriptor | Plasmepsin-2, ~{N}1-[(~{Z},3~{R})-4-[2-(3-methoxyphenyl)propan-2-ylamino]-3-oxidanyl-1-phenyl-but-1-en-2-yl]-5-piperidin-1-yl-~{N}3,~{N}3-dipropyl-benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | plasmepsin ii hydroxyethylamine-basd inhibitor, hydrolase |
Biological source | Plasmodium falciparum |
Cellular location | Vacuole: P46925 |
Total number of polymer chains | 3 |
Total formula weight | 113336.33 |
Authors | Recacha, R.,Akopjana, I.,Tars, K.,Jaudzems, K. (deposition date: 2015-02-13, release date: 2015-12-09, Last modification date: 2024-01-10) |
Primary citation | Recacha, R.,Leitans, J.,Akopjana, I.,Aprupe, L.,Trapencieris, P.,Jaudzems, K.,Jirgensons, A.,Tars, K. Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors. Acta Crystallogr.,Sect.F, 71:1531-1539, 2015 Cited by PubMed: 26625296DOI: 10.1107/S2053230X15022049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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