4Y6K

Complex structure of presenilin homologue PSH bound to an inhibitor

Summary for 4Y6K

• Entry DOI: 10.2210/pdb4y6k/pdb
• Related PRD ID: PRD_002147
• Descriptor: Uncharacterized protein PSH, N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide (2 entities in total)
• Functional Keywords: complex, inhibitor, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Methanoculleus marisnigri JR1
• Total number of polymer chains: 4
• Total formula weight: 128862.75

Authors

Dang, S.,Wu, S.,Wang, J.,Shi, Y. (deposition date: 2015-02-13, release date: 2015-03-18, Last modification date: 2023-11-08)

• Primary citation: Dang, S.,Wu, S.,Wang, J.,Li, H.,Huang, M.,He, W.,Li, Y.M.,Wong, C.C.,Shi, Y.; Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH; Proc.Natl.Acad.Sci.USA, 112:3344-3349, 2015; PubMed: 25733893; DOI: 10.1073/pnas.1502150112

Experimental method

X-RAY DIFFRACTION (3.855 Å)