4Y6G
Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site.
4Y6G の概要
エントリーDOI | 10.2210/pdb4y6g/pdb |
関連するPDBエントリー | 2CLE 2CLF 2WX2 4KKX 4XUG |
分子名称 | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total) |
機能のキーワード | lyase, tryptophan biosynthesis, salmonella typhimurium, f6f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
由来する生物種 | Salmonella enterica subsp. enterica serovar Typhimurium 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 72546.14 |
構造登録者 | Hilario, E.,Caulkins, B.G.,Young, R.P.,Dunn, M.F.,Mueller, L.J.,Fan, L. (登録日: 2015-02-13, 公開日: 2016-02-10, 最終更新日: 2023-09-27) |
主引用文献 | Hilario, E.,Caulkins, B.G.,Huang, Y.M.,You, W.,Chang, C.E.,Mueller, L.J.,Dunn, M.F.,Fan, L. Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water. Biochim.Biophys.Acta, 1864:268-279, 2016 Cited by PubMed: 26708480DOI: 10.1016/j.bbapap.2015.12.006 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
構造検証レポート
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