4Y3C

I304V 3D polymerase mutant of EMCV

Summary for 4Y3C

• Entry DOI: 10.2210/pdb4y3c/pdb
• Related: 4Y2C
• Descriptor: 3D polymerase, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: rna dependent rna polymerase cardiovirus inhibitor resistance, viral protein
• Biological source: Mengo encephalomyocarditis virus
• Cellular location: Protein 2A: Host nucleus . Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B: Virion . Protease 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P12296
• Total number of polymer chains: 6
• Total formula weight: 314339.25

Authors

Verdaguer, N.,Ferrer-Orta, C.,Vives-Adrian, L. (deposition date: 2015-02-10, release date: 2015-04-01, Last modification date: 2024-01-10)

• Primary citation: van der Linden, L.,Vives-Adrian, L.,Selisko, B.,Ferrer-Orta, C.,Liu, X.,Lanke, K.,Ulferts, R.,De Palma, A.M.,Tanchis, F.,Goris, N.,Lefebvre, D.,De Clercq, K.,Leyssen, P.,Lacroix, C.,Purstinger, G.,Coutard, B.,Canard, B.,Boehr, D.D.,Arnold, J.J.,Cameron, C.E.,Verdaguer, N.,Neyts, J.,van Kuppeveld, F.J.; The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.; Plos Pathog., 11:e1004733-e1004733, 2015; PubMed: 25799064; DOI: 10.1371/journal.ppat.1004733

Experimental method

X-RAY DIFFRACTION (3.2 Å)