4Y3C
I304V 3D polymerase mutant of EMCV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0039694 | biological_process | viral RNA genome replication |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0039694 | biological_process | viral RNA genome replication |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| F | 0006351 | biological_process | DNA-templated transcription |
| F | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| D | TYR331 |
| D | ARG382 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | ARG16 |
| D | SER39 |
| D | LYS40 |
| D | PHE41 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| F | LYS267 |
| F | GLU271 |
| D | THR447 |
| D | SER450 |
| F | PHE248 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 504 |
| Chain | Residue |
| D | ARG16 |
| D | THR18 |
| D | LEU38 |
| D | SER39 |
| D | ASP42 |
| D | ARG44 |
| F | PHE459 |
| F | TRP460 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | GLY410 |
| D | LEU412 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 501 |
| Chain | Residue |
| A | ARG439 |
| E | TYR318 |
| E | ASN344 |
| E | ARG347 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL E 503 |
| Chain | Residue |
| A | PRO43 |
| A | ASP46 |
| E | PRO409 |
| E | GLY410 |
| E | THR411 |
| E | LEU412 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 501 |
| Chain | Residue |
| F | VAL153 |
| F | ARG284 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL F 502 |
| Chain | Residue |
| D | SER413 |
| D | VAL443 |
| F | THR63 |
| F | LEU64 |
| F | PRO65 |
| F | LYS354 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 503 |
| Chain | Residue |
| F | ALA53 |
| F | PHE54 |
| F | ILE175 |
| F | TYR285 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: For RdRp activity => ECO:0000269|PubMed:24600002 |
| Chain | Residue | Details |
| A | ASP235 | |
| E | ASP333 | |
| F | ASP235 | |
| F | ASP333 | |
| A | ASP333 | |
| B | ASP235 | |
| B | ASP333 | |
| C | ASP235 | |
| C | ASP333 | |
| D | ASP235 | |
| D | ASP333 | |
| E | ASP235 |
