4Y2C

M300V 3D polymerase mutant of EMCV

4Y2C の概要

• エントリーDOI: 10.2210/pdb4y2c/pdb
• 関連するPDBエントリー: 4NYZ 4NZ0
• 分子名称: Genome polyprotein, GLYCEROL (3 entities in total)
• 機能のキーワード: rna dependent rna polymerase cardiovirus inhibitor resistance, viral protein
• 由来する生物種: Mengo encephalomyocarditis virus
• 細胞内の位置: Protein 2A: Host nucleus . Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B: Virion . Protease 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P12296
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52580.81

構造登録者

Verdaguer, N.,Ferrer-Orta, C.,Vives-Adrian, L. (登録日: 2015-02-09, 公開日: 2015-04-01, 最終更新日: 2024-01-10)

• 主引用文献: van der Linden, L.,Vives-Adrian, L.,Selisko, B.,Ferrer-Orta, C.,Liu, X.,Lanke, K.,Ulferts, R.,De Palma, A.M.,Tanchis, F.,Goris, N.,Lefebvre, D.,De Clercq, K.,Leyssen, P.,Lacroix, C.,Purstinger, G.,Coutard, B.,Canard, B.,Boehr, D.D.,Arnold, J.J.,Cameron, C.E.,Verdaguer, N.,Neyts, J.,van Kuppeveld, F.J.; The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.; Plos Pathog., 11:e1004733-e1004733, 2015; PubMed: 25799064; DOI: 10.1371/journal.ppat.1004733

実験手法

X-RAY DIFFRACTION (2.2 Å)