4Y29

Identification of a novel PPARg ligand that regulates metabolism

Summary for 4Y29

• Entry DOI: 10.2210/pdb4y29/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, ... (4 entities in total)
• Functional Keywords: af-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator pparg, nr1c3, peroxisome proliferator-activated receptor gamma, nhr, nuclear receptor, coactivator, transcription factor, dna binding protein-transcription complex, dna binding protein/transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P37231 Q15788
• Total number of polymer chains: 2
• Total formula weight: 32226.49

Authors

Wang, R.,Li, Y. (deposition date: 2015-02-09, release date: 2015-09-09, Last modification date: 2023-11-08)

• Primary citation: Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y.; Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.; Sci Rep, 5:12222-12222, 2015; PubMed: 26183621; DOI: 10.1038/srep12222

Experimental method

X-RAY DIFFRACTION (1.98 Å)