4Y14

Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)

4Y14 の概要

• エントリーDOI: 10.2210/pdb4y14/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
• 機能のキーワード: tyrosine inhibitor complex, hydrolase, protein binding, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73159.69

構造登録者

Choy, M.S.,Connors, C.,Page, R.,Peti, W. (登録日: 2015-02-06, 公開日: 2015-08-05, 最終更新日: 2023-09-27)

• 主引用文献: Krishnan, N.,Krishnan, K.,Connors, C.R.,Choy, M.S.,Page, R.,Peti, W.,Van Aelst, L.,Shea, S.D.,Tonks, N.K.; PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.; J.Clin.Invest., 125:3163-3177, 2015; PubMed: 26214522; DOI: 10.1172/JCI80323

実験手法

X-RAY DIFFRACTION (1.898 Å)