4XUF

Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

Summary for 4XUF

• Entry DOI: 10.2210/pdb4xuf/pdb
• Descriptor: Receptor-type tyrosine-protein kinase FLT3, 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea (3 entities in total)
• Functional Keywords: flt3, receptor tyrosine kinase, ac220, quizartinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69085.44

Authors

Zorn, J.A.,Wang, Q.,Fujimura, E.,Barros, T.,Kuriyan, J. (deposition date: 2015-01-25, release date: 2015-04-15, Last modification date: 2023-09-27)

• Primary citation: Zorn, J.A.,Wang, Q.,Fujimura, E.,Barros, T.,Kuriyan, J.; Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220).; Plos One, 10:e0121177-e0121177, 2015; PubMed: 25837374; DOI: 10.1371/journal.pone.0121177

Experimental method

X-RAY DIFFRACTION (3.2 Å)