4XUF
Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)
Summary for 4XUF
Entry DOI | 10.2210/pdb4xuf/pdb |
Descriptor | Receptor-type tyrosine-protein kinase FLT3, 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea (3 entities in total) |
Functional Keywords | flt3, receptor tyrosine kinase, ac220, quizartinib, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69085.44 |
Authors | Zorn, J.A.,Wang, Q.,Fujimura, E.,Barros, T.,Kuriyan, J. (deposition date: 2015-01-25, release date: 2015-04-15, Last modification date: 2023-09-27) |
Primary citation | Zorn, J.A.,Wang, Q.,Fujimura, E.,Barros, T.,Kuriyan, J. Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220). Plos One, 10:e0121177-e0121177, 2015 Cited by PubMed: 25837374DOI: 10.1371/journal.pone.0121177 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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