4XUF

Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor-type tyrosine-protein kinase FLT3	polymer	297	33982.1	2	UniProt (P36888) Pfam (PF07714)	Homo sapiens (Human)	FL cytokine receptor,Fetal liver kinase-2,FLK-2,Fms-like tyrosine kinase 3,FLT-3,Stem cell tyrosine kinase 1,STK-1
2	C, D (A, B)	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	non-polymer		560.7	2	Chemie (P30)
3	E (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 600 - 710 (UniProt: P36888)
A, B: 762 - 947 (UniProt: P36888)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67964.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1121.3
All*	Total formula weight	69085.4

*Water molecules are not included.