4XT9
RORgamma (263-509) complexed with GSK2435341A and SRC2
Summary for 4XT9
Entry DOI | 10.2210/pdb4xt9/pdb |
Descriptor | Nuclear receptor ROR-gamma, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, ... (5 entities in total) |
Functional Keywords | unknown protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 2 |
Total formula weight | 30054.72 |
Authors | |
Primary citation | Wang, Y.,Yang, T.,Liu, Q.,Ma, Y.,Yang, L.,Zhou, L.,Xiang, Z.,Cheng, Z.,Lu, S.,Orband-Miller, L.A.,Zhang, W.,Wu, Q.,Zhang, K.,Li, Y.,Xiang, J.N.,Elliott, J.D.,Leung, S.,Ren, F.,Lin, X. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists Bioorg.Med.Chem., 23:5293-5302, 2015 Cited by PubMed: 26277758DOI: 10.1016/j.bmc.2015.07.068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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