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4XT9

RORgamma (263-509) complexed with GSK2435341A and SRC2

Summary for 4XT9
Entry DOI10.2210/pdb4xt9/pdb
DescriptorNuclear receptor ROR-gamma, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, ... (5 entities in total)
Functional Keywordsunknown protein
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : P51449
Total number of polymer chains2
Total formula weight30054.72
Authors
Wang, Y.,Ma, Y. (deposition date: 2015-01-23, release date: 2015-08-12, Last modification date: 2023-11-08)
Primary citationWang, Y.,Yang, T.,Liu, Q.,Ma, Y.,Yang, L.,Zhou, L.,Xiang, Z.,Cheng, Z.,Lu, S.,Orband-Miller, L.A.,Zhang, W.,Wu, Q.,Zhang, K.,Li, Y.,Xiang, J.N.,Elliott, J.D.,Leung, S.,Ren, F.,Lin, X.
Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
Bioorg.Med.Chem., 23:5293-5302, 2015
Cited by
PubMed: 26277758
DOI: 10.1016/j.bmc.2015.07.068
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

217705

數據於2024-03-27公開中

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