4XT8
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimetrexate
Summary for 4XT8
| Entry DOI | 10.2210/pdb4xt8/pdb |
| Related | 4XRB 4XT4 4XT5 4XT6 4XT7 |
| Descriptor | Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (7 entities in total) |
| Functional Keywords | trimetrexate, reductase, structural genomics, tb structural genomics consortium, tbsgc, oxidoreductase |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 1 |
| Total formula weight | 29263.79 |
| Authors | Sacchettini, J.C.,Cheng, Y.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-01-23, release date: 2016-02-24, Last modification date: 2023-09-27) |
| Primary citation | Cheng, Y.S.,Sacchettini, J.C. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55:1107-1119, 2016 Cited by PubMed: 26848874DOI: 10.1021/acs.biochem.5b00993 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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