4XT8

Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimetrexate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005829	cellular_component	cytosol
A	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
A	0009231	biological_process	riboflavin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue NAP A 301

Chain	Residue
A	PHE45
A	GLY86
A	THR87
A	ILE90
A	GLU91
A	VAL120
A	THR121
A	ARG122
A	SER123
A	VAL173
A	GLU175
A	ILE46
A	GLU193
A	GLY194
A	GLY195
A	PRO196
A	THR197
A	LEU198
A	THR201
A	ARG225
A	TMQ302
A	PEG305
A	ALA53
A	HOH440
A	HOH441
A	HOH443
A	HOH446
A	THR54
A	GLY57
A	THR58
A	SER59
A	GLY84
A	VAL85

---

site_id	AC2
Number of Residues	13
Details	binding site for residue TMQ A 302

Chain	Residue
A	ASN44
A	PHE45
A	ILE46
A	SER59
A	ALA63
A	ASP67
A	PHE71
A	ARG75
A	GLU91
A	GLU193
A	THR214
A	NAP301
A	HOH465

---

site_id	AC3
Number of Residues	7
Details	binding site for residue PEG A 303

Chain	Residue
A	LEU16
A	LEU17
A	CYS240
A	HIS242
A	VAL243
A	THR245
A	HOH422

---

site_id	AC4
Number of Residues	12
Details	binding site for residue GOL A 304

Chain	Residue
A	ALA61
A	MET62
A	ALA63
A	GLY64
A	PRO65
A	THR146
A	ALA164
A	SER166
A	GLN181
A	TYR218
A	TYR250
A	EDO306

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PEG A 305

Chain	Residue
A	ARG122
A	THR197
A	NAP301

---

site_id	AC6
Number of Residues	8
Details	binding site for residue EDO A 306

Chain	Residue
A	GLY64
A	PRO65
A	GLY66
A	THR146
A	ASP246
A	SER248
A	TYR250
A	GOL304

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 307

Chain	Residue
A	ASP79
A	ARG106
A	GLN111
A	SER112
A	LEU187
A	HOH469

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