4XT7

Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimethoprim

Summary for 4XT7

Entry DOI	10.2210/pdb4xt7/pdb
Related	4XRB 4XT4 4XT5 4XT6 4XT8
Descriptor	Rv2671, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (6 entities in total)
Functional Keywords	trimethoprim, reductase, structural genomics, tb structural genomics consortium, tbsgc, oxidoreductase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	28953.43
Authors	Sacchettini, J.C.,Cheng, Y.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-01-23, release date: 2016-02-24, Last modification date: 2023-09-27)
Primary citation	Cheng, Y.S.,Sacchettini, J.C. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55:1107-1119, 2016 Cited by PubMed: 26848874 DOI: 10.1021/acs.biochem.5b00993 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation