4XT7

Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimethoprim

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005829	cellular_component	cytosol
A	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
A	0009231	biological_process	riboflavin biosynthetic process
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue NAP A 301

Chain	Residue
A	PHE45
A	GLY86
A	THR87
A	ILE90
A	GLU91
A	VAL120
A	THR121
A	ARG122
A	SER123
A	VAL173
A	GLU175
A	ILE46
A	GLU193
A	GLY195
A	PRO196
A	THR197
A	LEU198
A	THR201
A	TOP302
A	HOH439
A	HOH440
A	HOH458
A	ALA53
A	HOH466
A	THR54
A	GLY57
A	THR58
A	SER59
A	GLY84
A	VAL85

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site_id	AC2
Number of Residues	14
Details	binding site for residue TOP A 302

Chain	Residue
A	ASN44
A	PHE45
A	ILE46
A	SER59
A	GLY60
A	ASP67
A	ARG68
A	PHE71
A	GLU91
A	GLU193
A	THR214
A	NAP301
A	GOL303
A	HOH435

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site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG75
A	GLU91
A	TYR93
A	TOP302
A	HOH460

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site_id	AC4
Number of Residues	7
Details	binding site for residue PEG A 304

Chain	Residue
A	GLY60
A	ARG68
A	ASP174
A	VAL177
A	SER180
A	ARG205
A	HOH411

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