4XT3

Structure of a viral GPCR bound to human chemokine CX3CL1

Summary for 4XT3

• Entry DOI: 10.2210/pdb4xt3/pdb
• Related: 4XT1
• Related PRD ID: PRD_900017
• Descriptor: G-protein coupled receptor homolog US28, Fractalkine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: gpcr, chemokine, membrane protein, complex, viral protein-cytokine complex, viral protein-signalling protein complex, viral protein/signalling protein
• Biological source: Cytomegalovirus; More
• Total number of polymer chains: 2
• Total formula weight: 52872.12

Authors

Burg, J.S.,Jude, K.M.,Waghray, D.,Garcia, K.C. (deposition date: 2015-01-22, release date: 2015-03-04, Last modification date: 2023-09-27)

• Primary citation: Burg, J.S.,Ingram, J.R.,Venkatakrishnan, A.J.,Jude, K.M.,Dukkipati, A.,Feinberg, E.N.,Angelini, A.,Waghray, D.,Dror, R.O.,Ploegh, H.L.,Garcia, K.C.; Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.; Science, 347:1113-1117, 2015; PubMed: 25745166; DOI: 10.1126/science.aaa5026

Experimental method

X-RAY DIFFRACTION (3.801 Å)