4XMK

Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 in complex with JR-FL V3 peptide

Summary for 4XMK

• Entry DOI: 10.2210/pdb4xmk/pdb
• Related: 4XMK
• Descriptor: Light chain of HIV-1 gp120 V3-specific human monoclonal antibody 2424, Heavy chain of HIV-1 gp120 V3-specific human monoclonal antibody 2424, HIV-1 JR-FL gp120 V3 peptide (3 entities in total)
• Functional Keywords: hiv-1 gp120, monoclonal antibody, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 9
• Total formula weight: 145389.11

Authors

Kong, X.-P.,Pan, R. (deposition date: 2015-01-14, release date: 2015-07-08, Last modification date: 2019-12-11)

• Primary citation: Kumar, R.,Pan, R.,Upadhyay, C.,Mayr, L.,Cohen, S.,Wang, X.H.,Balasubramanian, P.,Nadas, A.,Seaman, M.S.,Zolla-Pazner, S.,Gorny, M.K.,Kong, X.P.,Hioe, C.E.; Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL.; J.Virol., 89:9090-9102, 2015; PubMed: 26109728; DOI: 10.1128/JVI.01280-15

Experimental method

X-RAY DIFFRACTION (3.179 Å)