4XLV

Crystal structure of the activated insulin receptor tyrosine kinase dimer

Summary for 4XLV

Entry DOI	10.2210/pdb4xlv/pdb
Descriptor	Insulin receptor, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	tyrosine kinase, signal transduction, phosphoryl transfer, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37911.83
Authors	Hubbard, S.R.,Li, S. (deposition date: 2015-01-13, release date: 2015-03-25, Last modification date: 2019-12-25)
Primary citation	Cabail, M.Z.,Li, S.,Lemmon, E.,Bowen, M.E.,Hubbard, S.R.,Miller, W.T. The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. Nat Commun, 6:6406-6406, 2015 Cited by PubMed: 25758790 DOI: 10.1038/ncomms7406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation