4XLD

Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction

4XLD の概要

• エントリーDOI: 10.2210/pdb4xld/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, FORMIC ACID, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total)
• 機能のキーワード: nuclear receptor ligand screening, gene regulation
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34155.52

構造登録者

Delfosse, V.,Guichou, J.-F. (登録日: 2015-01-13, 公開日: 2015-08-12, 最終更新日: 2024-01-10)

• 主引用文献: Gelin, M.,Delfosse, V.,Allemand, F.,Hoh, F.,Sallaz-Damaz, Y.,Pirocchi, M.,Bourguet, W.,Ferrer, J.L.,Labesse, G.,Guichou, J.F.; Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.; Acta Crystallogr.,Sect.D, 71:1777-1787, 2015; PubMed: 26249358; DOI: 10.1107/S1399004715010342

実験手法

X-RAY DIFFRACTION (2.45 Å)