4XEG

Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch

Summary for 4XEG

• Entry DOI: 10.2210/pdb4xeg/pdb
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: dna glycosylase, abasic site, enzyme-product complex, 5-hydroxymethyluracil, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 40494.96

Authors

Pozharski, E.,Malik, S.S.,Drohat, A.C. (deposition date: 2014-12-23, release date: 2015-09-09, Last modification date: 2023-09-27)

• Primary citation: Malik, S.S.,Coey, C.T.,Varney, K.M.,Pozharski, E.,Drohat, A.C.; Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.; Nucleic Acids Res., 43:9541-9552, 2015; PubMed: 26358812; DOI: 10.1093/nar/gkv890

Experimental method

X-RAY DIFFRACTION (1.72 Å)