4XCU

Crystal Structure of FGFR4 with an Irreversible Inhibitor

4XCU の概要

• エントリーDOI: 10.2210/pdb4xcu/pdb
• 分子名称: Fibroblast growth factor receptor 4, SULFATE ION, N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, hepatocellular carcinoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34474.67

構造登録者

Kim, J.L.,Miduturu, C.,Hodous, B.,Brooijmans, N.,Bifulco, N.,Guzi, T. (登録日: 2014-12-18, 公開日: 2015-04-01, 最終更新日: 2018-12-12)

• 主引用文献: Hagel, M.,Miduturu, C.,Sheets, M.,Rubin, N.,Weng, W.,Stransky, N.,Bifulco, N.,Kim, J.L.,Hodous, B.,Brooijmans, N.,Shutes, A.,Winter, C.,Lengauer, C.,Kohl, N.E.,Guzi, T.; First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.; Cancer Discov, 5:424-437, 2015; PubMed: 25776529; DOI: 10.1158/2159-8290.CD-14-1029

実験手法

X-RAY DIFFRACTION (1.71 Å)