4X8T

FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 7-chloro-3,4-dihydroisoquinolin-1(2H)-one

4X8T の概要

• エントリーDOI: 10.2210/pdb4x8t/pdb
• 関連するPDBエントリー: 4X8S 4X8U 4X8V
• 分子名称: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, ... (7 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P08709 P08709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34736.06

構造登録者

Wei, A. (登録日: 2014-12-10, 公開日: 2015-03-25, 最終更新日: 2015-04-08)

• 主引用文献: Cheney, D.L.,Bozarth, J.M.,Metzler, W.J.,Morin, P.E.,Mueller, L.,Newitt, J.A.,Nirschl, A.H.,Rendina, A.R.,Tamura, J.K.,Wei, A.,Wen, X.,Wurtz, N.R.,Seiffert, D.A.,Wexler, R.R.,Priestley, E.S.; Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening.; J.Med.Chem., 58:2799-2808, 2015; PubMed: 25764119; DOI: 10.1021/jm501982k

実験手法

X-RAY DIFFRACTION (2.2 Å)