4X48
Crystal structure of GluR2 ligand-binding core
Summary for 4X48
Entry DOI | 10.2210/pdb4x48/pdb |
Related | 4LZ5 4LZ7 4LZ8 |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (5 entities in total) |
Functional Keywords | ampa receptor, allosteric modulator, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 3 |
Total formula weight | 92584.94 |
Authors | Pandit, J. (deposition date: 2014-12-02, release date: 2015-05-06, Last modification date: 2023-09-27) |
Primary citation | Shaffer, C.L.,Patel, N.C.,Schwarz, J.,Scialis, R.J.,Wei, Y.,Hou, X.J.,Xie, L.,Karki, K.,Bryce, D.K.,Osgood, S.M.,Hoffmann, W.E.,Lazzaro, J.T.,Chang, C.,McGinnis, D.F.,Lotarski, S.M.,Liu, J.,Obach, R.S.,Weber, M.L.,Chen, L.,Zasadny, K.R.,Seymour, P.A.,Schmidt, C.J.,Hajos, M.,Hurst, R.S.,Pandit, J.,O'Donnell, C.J. The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242). J.Med.Chem., 58:4291-4308, 2015 Cited by PubMed: 25905800DOI: 10.1021/acs.jmedchem.5b00300 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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