4X41

Crystal Structure of Protein Arginine Methyltransferase PRMT8

Summary for 4X41

Entry DOI	10.2210/pdb4x41/pdb
Descriptor	Protein arginine N-methyltransferase 8, S-ADENOSYL-L-HOMOCYSTEINE (2 entities in total)
Functional Keywords	protein arginine methyltransferase, methylation, dimerization, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Lipid-anchor ; Cytoplasmic side : Q9NR22
Total number of polymer chains	2
Total formula weight	83613.45
Authors	Lee, W.C.,Ho, M.C. (deposition date: 2014-12-02, release date: 2015-11-18, Last modification date: 2024-03-20)
Primary citation	Lee, W.C.,Lin, W.L.,Matsui, T.,Chen, E.S.,Wei, T.Y.,Lin, W.H.,Hu, H.,Zheng, Y.G.,Tsai, M.D.,Ho, M.C. Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity Biochemistry, 54:7514-7523, 2015 Cited by PubMed: 26529540 DOI: 10.1021/acs.biochem.5b00995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation