4X3V

Crystal structure of human ribonucleotide reductase 1 bound to inhibitor

4X3V の概要

• エントリーDOI: 10.2210/pdb4x3v/pdb
• 分子名称: Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine (3 entities in total)
• 機能のキーワード: complex, reducatse, inhibitor, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 181740.83

構造登録者

Dealwis, C.G.,Ahmad, M.F.,Alam, I. (登録日: 2014-12-01, 公開日: 2015-11-11, 最終更新日: 2023-09-27)

• 主引用文献: Ahmad, M.F.,Huff, S.E.,Pink, J.,Alam, I.,Zhang, A.,Perry, K.,Harris, M.E.,Misko, T.,Porwal, S.K.,Oleinick, N.L.,Miyagi, M.,Viswanathan, R.,Dealwis, C.G.; Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.; J.Med.Chem., 58:9498-9509, 2015; PubMed: 26488902; DOI: 10.1021/acs.jmedchem.5b00929

実験手法

X-RAY DIFFRACTION (3.7 Å)