4X0Z

JC Polyomavirus genotype 3 VP1 in complex with GM1 oligosaccharide

Summary for 4X0Z

• Entry DOI: 10.2210/pdb4x0z/pdb
• Related: 3NXD 3NXG
• Descriptor: Major capsid protein, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: beta-sandwich, jelly-roll, viral capsid protein, glycan, viral protein
• Biological source: JC polyomavirus type 3 (JCPyV)
• Total number of polymer chains: 5
• Total formula weight: 156065.28

Authors

Stroh, L.J.,Stehle, T. (deposition date: 2014-11-24, release date: 2015-04-22, Last modification date: 2024-01-10)

• Primary citation: Stroh, L.J.,Maginnis, M.S.,Blaum, B.S.,Nelson, C.D.,Neu, U.,Gee, G.V.,O'Hara, B.A.,Motamedi, N.,DiMaio, D.,Atwood, W.J.,Stehle, T.; The Greater Affinity of JC Polyomavirus Capsid for alpha 2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity.; J.Virol., 89:6364-6375, 2015; PubMed: 25855729; DOI: 10.1128/JVI.00489-15

Experimental method

X-RAY DIFFRACTION (1.85 Å)