4X0P
Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog
Summary for 4X0P
Entry DOI | 10.2210/pdb4x0p/pdb |
Related | 4X0Q |
Descriptor | DNA polymerase theta, DNA (5'-D(P*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*C)-3'), DNA (5'-D(*CP*GP*TP*TP*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), ... (6 entities in total) |
Functional Keywords | dna polymerase alternative end-joining translesion dna synthesis cancer, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 399140.66 |
Authors | Zahn, K.E.,Doublie, S. (deposition date: 2014-11-21, release date: 2015-03-18, Last modification date: 2023-09-27) |
Primary citation | Zahn, K.E.,Averill, A.M.,Aller, P.,Wood, R.D.,Doublie, S. Human DNA polymerase theta grasps the primer terminus to mediate DNA repair. Nat.Struct.Mol.Biol., 22:304-311, 2015 Cited by PubMed: 25775267DOI: 10.1038/nsmb.2993 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.911 Å) |
Structure validation
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