4X0P

Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL A 2601

Chain	Residue
A	MET2427
A	GLU2465

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 2602

Chain	Residue
A	ASP1966
A	ILE1968
A	VAL2232
A	SER2233

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CA A 2603

Chain	Residue
A	DDS2604
A	ASP2330
A	TYR2331
A	ASP2540

---

site_id	AC4
Number of Residues	15
Details	binding site for residue DDS A 2604

Chain	Residue
A	ASP2330
A	TYR2331
A	GLN2333
A	GLU2335
A	ARG2379
A	LYS2383
A	GLN2384
A	TYR2387
A	TYR2391
A	GLN2474
A	ASP2540
A	LYS2575
A	CA2603
E	DG5
F	DC13

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL B 2601

Chain	Residue
B	MET2427
B	GLU2465

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL B 2602

Chain	Residue
B	ASP1966
B	ILE1968
B	GLN1969
B	LYS1990
B	VAL2232

---

site_id	AC7
Number of Residues	5
Details	binding site for residue CA B 2603

Chain	Residue
B	ASP2330
B	TYR2331
B	GLN2333
B	ASP2540
B	DDS2604

---

site_id	AC8
Number of Residues	14
Details	binding site for residue DDS B 2604

Chain	Residue
B	ASP2330
B	TYR2331
B	GLN2333
B	GLU2335
B	PHE2359
B	ARG2379
B	LYS2383
B	GLN2384
B	TYR2387
B	ASP2540
B	LYS2575
B	CA2603
G	DG5
H	DC13

---

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL C 2601

Chain	Residue
C	MET2427
C	GLU2465

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL C 2602

Chain	Residue
C	ASP1966
C	ILE1968
C	GLN1969
C	VAL2232
C	SER2233

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CA C 2603

Chain	Residue
C	ASP2330
C	TYR2331
C	ASP2540
C	DDS2604

---

site_id	AD3
Number of Residues	14
Details	binding site for residue DDS C 2604

Chain	Residue
C	ASP2330
C	TYR2331
C	GLN2333
C	GLU2335
C	ARG2379
C	LYS2383
C	GLN2384
C	TYR2387
C	TYR2391
C	GLN2474
C	ASP2540
C	CA2603
I	DG5
J	DC13

---

site_id	AD4
Number of Residues	1
Details	binding site for residue GOL D 2601

Chain	Residue
D	GLU2465

---

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL D 2602

Chain	Residue
D	ASP1966
D	ILE1968
D	VAL2232
D	SER2233

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CA D 2603

Chain	Residue
D	ASP2330
D	TYR2331
D	ASP2540
D	DDS2604

---

site_id	AD7
Number of Residues	11
Details	binding site for residue DDS D 2604

Chain	Residue
D	ASP2330
D	TYR2331
D	GLN2333
D	GLU2335
D	ARG2379
D	LYS2383
D	GLN2384
D	TYR2387
D	ASP2540
D	CA2603
L	DC13

---

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RqqAKqicYGiiYgmGaksL

Chain	Residue	Details
A	ARG2379-LEU2398

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:25775267, ECO:0007744|PDB:4X0Q

Chain	Residue	Details
A	ASP2330
D	ASP2330
D	TYR2331
D	ASP2540
A	TYR2331
A	ASP2540
B	ASP2330
B	TYR2331
B	ASP2540
C	ASP2330
C	TYR2331
C	ASP2540

---