4X0N
Porcine pancreatic alpha-amylase in complex with helianthamide, a novel proteinaceous inhibitor
Summary for 4X0N
Entry DOI | 10.2210/pdb4x0n/pdb |
Descriptor | Pancreatic alpha-amylase, Helianthamide, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | amylase, inhibitor, diabetes, protein inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 2 |
Total formula weight | 60236.67 |
Authors | Williams, L.K.,Brayer, G.D. (deposition date: 2014-11-21, release date: 2015-11-25, Last modification date: 2024-10-09) |
Primary citation | Tysoe, C.,Williams, L.K.,Keyzers, R.,Nguyen, N.T.,Aguda, A.,Zhang, X.,Tarling, C.A.,Andersen, R.J.,Brayer, G.D.,Withers, S.G. Structural Templating and Guided Refolding of the Potent Naturally Occurring Peptide Helianthamide Within the Active Site of Amylase, a Diabetes and Obesity Therapeutic Target To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.6001 Å) |
Structure validation
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