4X0F

Crystal structure of crosslink stabilized long-form PDE4B in complex with (R)-(-)-rolipram

Summary for 4X0F

• Entry DOI: 10.2210/pdb4x0f/pdb
• Related: 4WZI
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, IODIDE ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 150632.13

Authors

Cedervall, P.,Pandit, J. (deposition date: 2014-11-21, release date: 2015-03-11, Last modification date: 2023-09-27)

• Primary citation: Cedervall, P.,Aulabaugh, A.,Geoghegan, K.F.,McLellan, T.J.,Pandit, J.; Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.; Proc.Natl.Acad.Sci.USA, 112:E1414-E1422, 2015; PubMed: 25775568; DOI: 10.1073/pnas.1419906112

Experimental method

X-RAY DIFFRACTION (3.22 Å)