4WZV
Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain
Summary for 4WZV
Entry DOI | 10.2210/pdb4wzv/pdb |
Related | 4H1Q 4H2E 4H3X 4H82 4HMA |
Descriptor | Matrix metalloproteinase-9,Matrix metalloproteinase-9, GLYCEROL, (2R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-2-{[(4'-methoxybiphenyl-4-yl)sulfonyl](propan-2-yloxy)amino}butanamide, ... (11 entities in total) |
Functional Keywords | mmp9 inhibitor complex, thyroid hormone-binding protein, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space, extracellular matrix : P14780 |
Total number of polymer chains | 2 |
Total formula weight | 38442.89 |
Authors | Stura, E.A.,Vera, L.,Cassar-Lajeunesse, E.,Nuti, E.,Dive, V.,Rossello, A. (deposition date: 2014-11-20, release date: 2015-08-26, Last modification date: 2024-01-10) |
Primary citation | Nuti, E.,Cantelmo, A.R.,Gallo, C.,Bruno, A.,Bassani, B.,Camodeca, C.,Tuccinardi, T.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Martinelli, A.,Dive, V.,Albini, A.,Rossello, A. N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity. J.Med.Chem., 58:7224-7240, 2015 Cited by PubMed: 26263024DOI: 10.1021/acs.jmedchem.5b00367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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