4WZV
Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Matrix metalloproteinase-9,Matrix metalloproteinase-9 | polymer | 160 | 17904.9 | 2 | UniProt (P14780) Pfam (PF00413) | Homo sapiens (Human) | MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB |
| 2 | C, N (A, B) | (2R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-2-{[(4'-methoxybiphenyl-4-yl)sulfonyl](propan-2-yloxy)amino}butanamide | non-polymer | 567.6 | 2 | Chemie (E40) | Homo sapiens | ||
| 3 | D, E, O, P (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | F, G, H, Q, R... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 5 | I, T (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | J, K (A) | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 2 | Chemie (PGO) | |||
| 7 | DA, EA, L, M (B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 8 | U (B) | AZIDE ION | non-polymer | 42.0 | 1 | Chemie (AZI) | |||
| 9 | AA, BA, V, W, X... (B) | SODIUM ION | non-polymer | 23.0 | 7 | Chemie (NA) | |||
| 10 | CA (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 11 | FA, GA (A, B) | water | water | 18.0 | 630 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35809.7 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2633.2 | |
| All* | Total formula weight | 38442.9 |
