Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue E40 A 301 |
| Chain | Residue |
| A | LEU187 |
| A | HIS236 |
| A | LEU243 |
| A | TYR245 |
| A | PRO246 |
| A | MET247 |
| A | TYR248 |
| A | ZN302 |
| A | PGO308 |
| B | TYR245 |
| B | PRO246 |
| A | LEU188 |
| B | MET247 |
| A | ALA189 |
| A | HIS190 |
| A | ALA191 |
| A | HIS226 |
| A | GLU227 |
| A | HIS230 |
| A | ASP235 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | HIS226 |
| A | HIS230 |
| A | HIS236 |
| A | E40301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 303 |
| Chain | Residue |
| A | HIS175 |
| A | ASP177 |
| A | HIS190 |
| A | HIS203 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 304 |
| Chain | Residue |
| A | ASP165 |
| A | GLY197 |
| A | GLN199 |
| A | ASP201 |
| A | HOH699 |
| A | HOH703 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 305 |
| Chain | Residue |
| A | ASP131 |
| A | ASP206 |
| A | GLU208 |
| A | HOH804 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 306 |
| Chain | Residue |
| A | ASP182 |
| A | GLY183 |
| A | ASP185 |
| A | LEU187 |
| A | ASP205 |
| A | GLU208 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | VAL172 |
| A | ASP206 |
| A | ASP207 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PGO A 308 |
| Chain | Residue |
| A | ARG249 |
| A | THR251 |
| A | E40301 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PGO A 309 |
| Chain | Residue |
| A | ASP207 |
| A | HOH796 |
| A | HOH884 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 310 |
| Chain | Residue |
| A | HOH632 |
| A | HOH803 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 311 |
| Chain | Residue |
| A | VAL172 |
| A | HOH645 |
| A | HOH651 |
| site_id | AD3 |
| Number of Residues | 20 |
| Details | binding site for residue E40 B 301 |
| Chain | Residue |
| A | TYR245 |
| A | PRO246 |
| A | MET247 |
| B | LEU187 |
| B | LEU188 |
| B | ALA189 |
| B | HIS190 |
| B | ALA191 |
| B | LEU222 |
| B | HIS226 |
| B | GLU227 |
| B | HIS230 |
| B | ASP235 |
| B | HIS236 |
| B | LEU243 |
| B | TYR245 |
| B | PRO246 |
| B | MET247 |
| B | ZN302 |
| B | HOH915 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | HIS226 |
| B | HIS230 |
| B | HIS236 |
| B | E40301 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | HIS175 |
| B | ASP177 |
| B | HIS190 |
| B | HIS203 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 304 |
| Chain | Residue |
| B | ASP165 |
| B | GLY197 |
| B | GLN199 |
| B | ASP201 |
| B | HOH740 |
| B | HOH742 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 305 |
| Chain | Residue |
| B | ASP131 |
| B | ASP206 |
| B | GLU208 |
| B | HOH656 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 306 |
| Chain | Residue |
| B | LEU187 |
| B | ASP205 |
| B | GLU208 |
| B | ASP182 |
| B | GLY183 |
| B | ASP185 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| B | TYR160 |
| B | HOH627 |
| B | HOH640 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue AZI B 308 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 310 |
| Chain | Residue |
| B | PEG317 |
| B | HOH709 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 311 |
| Chain | Residue |
| A | HOH786 |
| A | HOH841 |
| B | HOH856 |
| B | HOH859 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 312 |
| Chain | Residue |
| B | ARG158 |
| B | HOH744 |
| B | HOH766 |
| B | HOH839 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 313 |
| Chain | Residue |
| B | SER238 |
| B | HOH835 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 314 |
| Chain | Residue |
| B | LYS184 |
| B | GLY217 |
| B | GLY269 |
| B | HOH626 |
| B | HOH660 |
| B | HOH680 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 315 |
| Chain | Residue |
| A | HOH730 |
| A | HOH813 |
| B | HOH753 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 316 |
| Chain | Residue |
| A | ALA146 |
| A | SER149 |
| B | GLU241 |
| B | PRO254 |
| B | LEU256 |
| B | HIS257 |
| B | HOH601 |
| B | HOH611 |
| B | HOH857 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 317 |
| Chain | Residue |
| B | NA310 |
| B | HOH613 |
| B | HOH653 |
| B | HOH766 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 318 |
| Chain | Residue |
| B | HOH794 |
| B | HOH806 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL |
| Chain | Residue | Details |
| A | VAL223-LEU232 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12077439","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
