Summary for 4WYV
| Entry DOI | 10.2210/pdb4wyv/pdb |
| Descriptor | Translin (2 entities in total) |
| Functional Keywords | translin, octomer, rna, open, barrel, rna binding protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : Q15631 |
| Total number of polymer chains | 8 |
| Total formula weight | 221003.98 |
| Authors | Dvir, H.,Eliahoo, E.,Alian, A. (deposition date: 2014-11-18, release date: 2014-11-26, Last modification date: 2024-01-10) |
| Primary citation | Eliahoo, E.,Marx, A.,Manor, H.,Alian, A. A novel open-barrel structure of octameric translin reveals a potential RNA entryway. J.Mol.Biol., 427:756-762, 2015 Cited by PubMed Abstract: The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation. Oligonucleotide binding surfaces map within a closed cavity of translin octameric barrels, raising the question as to how DNA/RNA gain access to this inner cavity, particularly given that, to date, none of the barrel structures reported hint to an entryway. Here, we argue against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. Additionally, we report that translin not only is confined to binding of ssDNA oligonucleotides, or single-stranded extensions of double-stranded DNA (dsDNA), but also can bind single-stranded sequences internally embedded in dsDNA molecules. PubMed: 25433126DOI: 10.1016/j.jmb.2014.11.013 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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