4WYO
Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 1
Summary for 4WYO
Entry DOI | 10.2210/pdb4wyo/pdb |
Related | 4WZ8 |
Descriptor | Acetyl-CoA carboxylase, 2'-tert-butyl-1-(2H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one (3 entities in total) |
Functional Keywords | acc, acetyl-coa, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 2 |
Total formula weight | 175256.62 |
Authors | Vajdos, F.F. (deposition date: 2014-11-17, release date: 2015-01-14, Last modification date: 2024-02-28) |
Primary citation | Griffith, D.A.,Kung, D.W.,Esler, W.P.,Amor, P.A.,Bagley, S.W.,Beysen, C.,Carvajal-Gonzalez, S.,Doran, S.D.,Limberakis, C.,Mathiowetz, A.M.,McPherson, K.,Price, D.A.,Ravussin, E.,Sonnenberg, G.E.,Southers, J.A.,Sweet, L.J.,Turner, S.M.,Vajdos, F.F. Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57:10512-10526, 2014 Cited by PubMed: 25423286DOI: 10.1021/jm5016022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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