4WWW
Crystal structure of the E. coli ribosome bound to CEM-101
This is a non-PDB format compatible entry.
Replaces: 4V80Replaces: 1VT2Replaces: 3OR9Replaces: 3ORAReplaces: 3ORBSummary for 4WWW
Entry DOI | 10.2210/pdb4www/pdb |
Descriptor | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... (56 entities in total) |
Functional Keywords | ribosomes, 70s, macrolide, ketolide, ribosome-antibiotic complex, ribosome/antibiotic |
Biological source | Escherichia coli str. K-12 substr. MG1655 More |
Total number of polymer chains | 104 |
Total formula weight | 4237893.94 |
Authors | Dunkle, J.A.,Zhang, W.,Cate, J.H.D.,Mankin, A.S. (deposition date: 2014-11-12, release date: 2014-12-24, Last modification date: 2023-09-27) |
Primary citation | Llano-Sotelo, B.,Dunkle, J.,Klepacki, D.,Zhang, W.,Fernandes, P.,Cate, J.H.,Mankin, A.S. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob. Agents Chemother., 54:4961-4970, 2010 Cited by PubMed: 20855725DOI: 10.1128/AAC.00860-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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