4WWW

Crystal structure of the E. coli ribosome bound to CEM-101

This is a non-PDB format compatible entry.

Replaces:  4V80Replaces:  1VT2Replaces:  3OR9Replaces:  3ORAReplaces:  3ORB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, VB (RA, YA)	23S rRNA	polymer	2904	941612.4	2	GenBank (545778205)	Escherichia coli str. K-12 substr. MG1655
2	B, WB (RB, YB)	5S rRNA	polymer	118	38177.8	2	GenBank (545778205)	Escherichia coli str. K-12 substr. MG1655
3	C, XB (RC, YC)	50S ribosomal protein L2	polymer	271	29663.2	2	UniProt (P60422) Pfam (PF00181) Pfam (PF03947)	Escherichia coli
4	D, YB (RD, YD)	50S ribosomal protein L3	polymer	209	22277.5	2	UniProt (P60438) Pfam (PF00297)	Escherichia coli
5	E, ZB (RE, YE)	50S ribosomal protein L4	polymer	201	22121.6	2	UniProt (P60723) Pfam (PF00573)	Escherichia coli
6	AC, F (RF, YF)	50S ribosomal protein L5	polymer	178	20202.4	2	UniProt (P62399) Pfam (PF00281) Pfam (PF00673)	Escherichia coli
7	BC, G (RG, YG)	50S ribosomal protein L6	polymer	176	18801.6	2	UniProt (P0AG55) Pfam (PF00347)	Escherichia coli
8	CC, H (RH, YH)	50S ribosomal protein L9	polymer	149	15789.0	2	UniProt (P0A7R1) Pfam (PF01281) Pfam (PF03948)	Escherichia coli
9	DC, I (RI, YI)	50S ribosomal protein L11	polymer	141	14763.2	2	UniProt (P0A7J7) Pfam (PF03946) Pfam (PF00298)	Escherichia coli
10	EC, J (RJ, YJ)	50S ribosomal protein L13	polymer	142	16050.6	2	UniProt (P0AA10) Pfam (PF00572)	Escherichia coli
11	FC, K (RK, YK)	50S ribosomal protein L14	polymer	122	13451.9	2	UniProt (P0ADY3) Pfam (PF00238)	Escherichia coli
12	GC, L (RL, YL)	50S ribosomal protein L15	polymer	143	14877.3	2	UniProt (P02413) Pfam (PF00828)	Escherichia coli
13	HC, M (RM, YM)	50S ribosomal protein L16	polymer	136	15312.3	2	UniProt (P0ADY7) Pfam (PF00252)	Escherichia coli
14	IC, N (RN, YN)	50S ribosomal protein L17	polymer	120	13721.9	2	UniProt (P0AG44) Pfam (PF01196)	Escherichia coli
15	JC, O (RO, YO)	50S ribosomal protein L18	polymer	116	12663.5	2	UniProt (P0C018) Pfam (PF00861)	Escherichia coli
16	KC, P (RP, YP)	50S ribosomal protein L19	polymer	114	13028.1	2	UniProt (P0A7K6) Pfam (PF01245)	Escherichia coli
17	LC, Q (RQ, YQ)	50S ribosomal protein L20	polymer	117	13396.8	2	UniProt (P0A7L3) Pfam (PF00453)	Escherichia coli
18	MC, R (RR, YR)	50S ribosomal protein L21	polymer	103	11586.4	2	UniProt (P0AG48) Pfam (PF00829)	Escherichia coli
19	NC, S (RS, YS)	50S ribosomal protein L22	polymer	110	12253.4	2	UniProt (P61175) Pfam (PF00237)	Escherichia coli
20	OC, T (RT, YT)	50S ribosomal protein L23	polymer	93	10546.5	2	UniProt (P0ADZ0) Pfam (PF00276)	Escherichia coli
21	PC, U (RU, YU)	50S ribosomal protein L24	polymer	102	11078.9	2	UniProt (P60624) Pfam (PF00467) Pfam (PF17136)	Escherichia coli
22	QC, V (RV, YV)	50S ribosomal protein L25	polymer	94	10713.5	2	UniProt (P68919) Pfam (PF01386)	Escherichia coli
23	RC, W (RW, YW)	50S ribosomal protein L27	polymer	79	8476.7	2	UniProt (P0A7L8) Pfam (PF01016)	Escherichia coli
24	SC, X (RX, YX)	50S ribosomal protein L28	polymer	77	8896.4	2	UniProt (P0A7M2) Pfam (PF00830)	Escherichia coli
25	TC, Y (RY, YY)	50S ribosomal protein L29	polymer	63	7286.5	2	UniProt (P0A7M6) Pfam (PF00831)	Escherichia coli
26	UC, Z (RZ, YZ)	50S ribosomal protein L30	polymer	58	6423.6	2	UniProt (P0AG51) Pfam (PF00327)	Escherichia coli
27	AA, VC (R0, Y0)	50S ribosomal protein L32	polymer	56	6332.2	2	UniProt (P0A7N4) Pfam (PF01783)	Escherichia coli
28	BA, WC (R1, Y1)	50S ribosomal protein L33	polymer	50	5814.8	2	UniProt (P0A7N9) Pfam (PF00471)	Escherichia coli
29	CA, XC (R2, Y2)	50S ribosomal protein L34	polymer	46	5397.5	2	UniProt (P0A7P5) Pfam (PF00468)	Escherichia coli
30	DA, YC (R3, Y3)	50S ribosomal protein L35	polymer	64	7181.8	2	UniProt (P0A7Q1) Pfam (PF01632)	Escherichia coli	Ribosomal protein A
31	EA, ZC (R4, Y4)	50S ribosomal protein L36	polymer	38	4377.4	2	UniProt (P0A7Q6) Pfam (PF00444)	Escherichia coli	Ribosomal protein B
32	AB, FA (QA, XA)	16S rRNA	polymer	1533	496892.4	2	GenBank (545778205)	Escherichia coli str. K-12 substr. MG1655
33	BB, GA (QB, XB)	30S ribosomal protein S2	polymer	218	24253.9	2	UniProt (P0A7V0) Pfam (PF00318)	Escherichia coli
34	CB, HA (QC, XC)	30S ribosomal protein S3	polymer	206	23078.8	2	UniProt (P0A7V3) Pfam (PF07650) Pfam (PF00189)	Escherichia coli
35	DB, IA (QD, XD)	30S ribosomal protein S4	polymer	205	23383.0	2	UniProt (P0A7V8) Pfam (PF00163) Pfam (PF01479)	Escherichia coli
36	EB, JA (QE, XE)	30S ribosomal protein S5	polymer	150	15804.3	2	UniProt (P0A7W1) Pfam (PF00333) Pfam (PF03719)	Escherichia coli
37	FB, KA (QF, XF)	30S ribosomal protein S6	polymer	100	11669.4	2	UniProt (P02358) Pfam (PF01250)	Escherichia coli
38	GB, LA (QG, XG)	30S ribosomal protein S7	polymer	151	16861.5	2	UniProt (P02359) Pfam (PF00177)	Escherichia coli
39	HB, MA (QH, XH)	30S ribosomal protein S8	polymer	129	14015.4	2	UniProt (P0A7W7) Pfam (PF00410)	Escherichia coli
40	IB, NA (QI, XI)	30S ribosomal protein S9	polymer	127	14554.9	2	UniProt (P0A7X3) Pfam (PF00380)	Escherichia coli
41	JB, OA (QJ, XJ)	30S ribosomal protein S10	polymer	98	11197.0	2	UniProt (P0A7R5) Pfam (PF00338)	Escherichia coli
42	KB, PA (QK, XK)	30S ribosomal protein S11	polymer	117	12487.2	2	UniProt (P0A7R9) Pfam (PF00411)	Escherichia coli
43	LB, QA (QL, XL)	30S ribosomal protein S12	polymer	123	13637.0	2	UniProt (P0A7S3) Pfam (PF00164)	Escherichia coli
44	MB, RA (QM, XM)	30S ribosomal protein S13	polymer	114	12625.8	2	UniProt (P0A7S9) Pfam (PF00416)	Escherichia coli
45	NB, SA (QN, XN)	30S ribosomal protein S14	polymer	101	11606.6	2	UniProt (P0AG59) Pfam (PF00253)	Escherichia coli
46	OB, TA (QO, XO)	30S ribosomal protein S15	polymer	88	10159.6	2	UniProt (P0ADZ4) Pfam (PF00312)	Escherichia coli
47	PB, UA (QP, XP)	30S ribosomal protein S16	polymer	82	9207.6	2	UniProt (P0A7T3) Pfam (PF00886)	Escherichia coli
48	QB, VA (QQ, XQ)	30S ribosomal protein S17	polymer	80	9263.9	2	UniProt (P0AG63) Pfam (PF00366)	Escherichia coli
49	RB, WA (QR, XR)	30S ribosomal protein S18	polymer	55	6466.5	2	UniProt (P0A7T7) Pfam (PF01084)	Escherichia coli
50	SB, XA (QS, XS)	30S ribosomal protein S19	polymer	79	9057.6	2	UniProt (P0A7U3) Pfam (PF00203)	Escherichia coli
51	TB, YA (QT, XT)	30S ribosomal protein S20	polymer	85	9506.2	2	UniProt (P0A7U7) Pfam (PF01649)	Escherichia coli
52	UB, ZA (QU, XU)	30S ribosomal protein S21	polymer	51	6067.1	2	UniProt (P68679) Pfam (PF01165)	Escherichia coli
53	AD, AE, AF, AG, AH... (RA, QA, XA, YA, RB...)	MAGNESIUM ION	non-polymer		24.3	361	Chemie (MG)
54	EI (RA)	(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside	non-polymer		845.0	1	Chemie (EM1)
55	KI, ZQ (R4, Y4)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
56	AR, AS, BR, BS, CR... (RA, YE, RB, YJ, RC...)	water	water		18.0	1708	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	104
	Total formula weight	4228144.0
Non-Polymers*	Number of molecules	364
	Total formula weight	9749.9
All*	Total formula weight	4237893.9

*Water molecules are not included.