4WVP

Crystal structure of an activity-based probe HNE complex

4WVP の概要

• エントリーDOI: 10.2210/pdb4wvp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002139
• 分子名称: Neutrophil elastase, BTN-3V3-NLB-OMT-OIC-3V2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: neutrophil elastase, acitivity-based probe, inhibitor, protease, complex, hne, hycosul, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26429.16

構造登録者

Lechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.R.,Drag, M.,Riedl, S.J. (登録日: 2014-11-06, 公開日: 2015-02-11, 最終更新日: 2023-11-15)

• 主引用文献: Lechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.,Drag, M.,Riedl, S.J.; The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed.; Acs Chem.Biol., 10:945-951, 2015; PubMed: 25581168; DOI: 10.1021/cb500909n

実験手法

X-RAY DIFFRACTION (1.63 Å)